Member of MSTP (MD/PhD) program
Undergraduate Institution and Major:
University of Minnesota, B.S., Neuroscience, 2015
Timothy Ebner, M.D., Ph.D., Department of Neuroscience
Description of Graduate Research:
My research focuses on the study of widespread cerebral cortical activation in the mouse. Using a Thy1-GCaMP6 line of transgenic mice and optically clear implanted windows, we are able to use fluorescent calcium imaging to view neuronal activity with high spatial and temporal resolution. The brain exhibits complex bilateral patterns of activation that vary over time. My project looks to analyze these patterns and correlate them to behaviors such as rest, locomotion, or whisker movement. I use mesoscopic calcium imaging to record activity across the mouse cortex during rest and behavior, and I analyze how this activity changes in different locations over time using computational models.
- Ghanbari L, Carter RE, Rynes ML, Dominguez J, Chen J, Naik A, Hu JJ, Kader Sagar MA, Haltom L, Mossazghi N, Grey MM, West SL, Eliceiri KW, Ebner T, Kodandaramaiah SB. See-Shells: Digitally generated transparent polymer skulls for cortex wide neural interfacing. Nat Commun. In review.
- West S, Popa LS, Carter RE, Chen G, Aronson JD, Ghanbari L, Kadandaramaiah SB, Ebner TJ. Mesoscopic imaging of the mouse cerebral cortex network dynamics during spontaneous behavior. Soceity for Neuroscience, 2018.
- Popa LS, West S, Carter RE, Chen G, Aronson JD, Ghanbari L, Kadandaramaiah SB, Ebner TJ. Functional interactions within the mouse cerebral cortical network during spontaneous behavior. Soceity for Neuroscience, 2018.
- NIMH T32 Fellow: Using Computation to Make Breakthroughs in Neuroscience
- Society for Neuroscience
- American Association for the Advancement of Science
Graduated with Honors, Summa Cum Laude, 2015
Undergraduate or Post-Bac Research:
During undergraduate, I studied movement planning and preparation in humans using magnetoencephalography (MEG) with Dr. Giuseppe Pellizzer. I also studied the electrophysiology of epilepsy in the lab of Dr. Theoden Netoff. There, I used both in vitro experiments and computational models to analyze seizure activity in the hippocampus.
What Got You Interested In Research?
I don’t think I ever accepted that one day I’d be completely trained for a job and would stop learning. Research is learning for a living.
Why Did You Choose MN?
Neuroscience at the University of Minnesota is well-respected and offers a large variety of opportunities. The Twin Cities have a vibrant culture that balances both a big city and a hometown feel.
Student Mentor and the Best Advice They Gave:
Amanda Barks: She told me that my GPN classmates would be one of my most important resources during graduate school, and that I should be sure to reach out to them early on.