Rebecca Speltz Paiz

Entering Class - 2015

Member of MSTP (MD/PhD) program


Undergraduate Institution and Major:

Hamline, B.S., Biochemistry, 2010

Graduate Advisors:


Description of Graduate Research:

My research centers on the novel bivalent ligand, MMG22, designed by the Portoghese lab to target the putative MOR-mGluR5 heterodimer. I will be using a combination of behavioral, electrophysiological, pharmacological, genetic and molecular techniques to study: 1) the efficacy and potency of MMG22 on a rodent model of peripheral neuropathic pain; 2) the development of tolerance to, and potential abuse liability, of MMG22; and 3) the importance of spinal mGluR5 expression on the development and maintenance of neuropathic pain.


Graduate Level Publications:

  • Leong ML, Speltz R, Wessendorf M. Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla. Neurosci Lett. 2016 Mar 23;617:82-87.

Professional Memberships:

  • Society for Neuroscience

Thesis Committee Members:

Research Categories:

  • Neurobiology of Pain & Somatosensation
  • Neuropharmaceutics
  • Neuroscience of Drug Abuse & Addiction


Why Did You Choose MN?

I chose Minnesota because of the amazing group of basic pain research faculty here and because of the collaborative nature of the neuroscience program as a whole. 

Rebecca Speltz Paiz