Marija Cvetanovic, Ph.D.

Assistant Professor, Department of Neuroscience


Research Interests:

Our lab aims to understand how different brain cells and their interactions influence the onset and progression of neurodegenerative diseases. The ultimate goal is to increase knowledge of these disorders and open new avenues for therapeutic approaches.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

  • Asher M, Rosa JC, Rainwater O, Duvick L, Bennyworth M, Lai RY, CRC-SCA, Kuo SH, Cvetanovic M. Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models. Hum Mol Genet. 2019 Nov 7. pii: ddz265.
  • Ferro A, Sheeler C, Cvetanovic M. Microglial self-recognition STINGs in A-T neurodegeneration. Trends Neurosci. 2019;42(11):753-755.
  • Mellesmoen A, Sheeler C, Ferro A, Rainwater O, Cvetanovic M. Brain derived neurotrophic factor (BDNF) delays onset of pathogenesis in transgenic mouse model of apinocerebellar ataxia type 1 (SCA1). Front Cell Neurosci. 2019 Jan 21;12:509.
  • Ferro A, Sheeler C, Rosa JG, Cvetanovic M. Role of microglia in ataxias. J Mol Biol. 2019;431(9):1792-1804.
  • Kim JH, Lukowicz A, Qu W, Johnson A, Cvetanovic M. Astroglia contribute to the pathogenesis of spinocerebellar ataxia Type 1 (SCA1) in a biphasic, stage-of-disease specific manner. Glia. 2018;66:1972-1987.
  • Ferro A, Qu W, Lukowicz A, Svedberg D, Johnson A, Cvetanovic M. Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1. PLoS One. 2018 Jul 5;13(7):e0200013.
  • Qu W, Johnson A, Kim JH, Lukowicz A, Svedberg D, Cvetanovic M. Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice. J Neuroinflammation. 2017;14(1):107.
  • Cvetanovic M, Hu YS, Opal P. Mutant ataxin-1 inhibits neural progenitor cell proliferation in SCA1. Cerebellum. 2017;16:340-347.
  • Stanojlovic M, Pang X, Lin Y, Stone S, Cvetanovic M, Lin W. Inhibition of vascular endothelial growth factor receptor 2 exacerbates loss of lower motor neurons and axons during experimental autoimmune encephalomyelitis. PLoS One. 2016;11(7):e0160158.
  • Asher M, Johnson A, Zecevic B, Pease D, Cvetanovic M. Ataxin-1 regulates proliferation of hippocampal neural precursors. Neuroscience. 2016;322:54-65.
  • Cvetanovic M, Ingram M, Orr H, Opal P. Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1. Neuroscience. 2015;289:289-299.
  • Cvetanovic M. Decreased expression of glutamate transporter GLAST in bergmann glia is associated with the loss of Purkinje neurons in the spinocerebellar ataxia type 1.Cerebellum. 2015;14:8-11.
  • Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014;23:3733-3745.
  • Cvetanovic M, Kular RK, Opal P. LANP, an inhibitor of histone acetyl transferase (INHAT) plays a role in Spinocerebellar ataxia 1. Neurobiol Dis. 2012;48:526-532.

Current Graduate Students:

Katherine Hamel (Neuroscience, University of Minnesota).

Carrie Sheeler (Neuroscience, University of Minnesota).

Austin Ferro (Neuroscience, University of Minnesota).

Former Graduate Students:

Melissa Asher (Masters, University of Minnesota)