Neural control of the splanchnic circulation in AngII-salt hypertension
General Surgery MD, Pennsylvania State College of Medicine, Milton S. Hershey Medical Center
Undergraduate Institution and Major/Degree:
B.S., Biomedical Engineering, 2005, Johns Hopkins University, Baltimore, MD
Penn State College of Medicine, Surgery Residency Program, Pennsylvania
I am interested in understanding the role of the central nervous system in the long term regulation of arterial pressure and in understanding the pathogenesis of essential hypertension. Using a rat model of experimental hypertension (AngII-Salt model) and techniques for continuous measurement of arterial pressure, blood flow, and peripheral nerve activity, I am studying the central effects of salt and Angiotensin-II (AngII) and its role in mediating functional changes in peripheral sympathetic organs during hypertension. Specifically, my focus is on the sympathetic influence to the splanchnic vascular bed and the mechanism and hemodynamic consequences of long term splanchnic vasoconstriction in hypertension. Parts of my current project will also look at the role of Neuropeptide-Y (NPY) in mediating changes seen in the splanchnic vascular bed in the AngII-Salt hypertensive rat.
Graduate Level Minor:
- Kuroki MT, Fink GD, Osborn JW. Comparison of arterial pressure and plasma ANG II responses to three methods of subcutaneous ANG II administration. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H670-679.
- Lund TC, Kobs AJ, Kramer A, Nyquist M, Kuroki MT, Osborn J, Lidke DS, Low-Nam ST, Blazar BR, Tolar J. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. PLoS One. 2013;8(3):e58945.
- Osborn JW, Kuroki MT. Sympathetic signatures of cardiovascular disease: a blueprint for development of targeted sympathetic ablation therapies. Hypertension. 2012;59(3):545-7.
- Kuroki MT, Guzman PA, Fink GD, Osborn JW. Time-dependent changes in autonomic control of splanchnic vascular resistance and heart rate in ANG II-salt hypertension. Am J Physiol Heart Circ Physiol. 2012;302(3):H763-9
- Osborn JW, Fink GD, Kuroki MT. Neural mechanisms of angiotensin II-salt hypertension: implications for therapies targeting neural control of the splanchnic circulation. Curr Hypertens Rep. 2011;13(3):221-8
Conferences Attended and Presentations:
- Society for Neuroscience - 2008
- Virginia Seybold - Chair
- John Osborn - Advisor
- William Engeland
- Zofia Zukowska (Dept of Integrative Biology and Physiology)
Awards and Honors:
- The Stark Award for Advanced Scholarship - 2010
- American Physiological Society
- Bauru, Sao Paulo, Brazil