Welcome to the GPN!

The Graduate Program in Neuroscience (GPN) at the University of Minnesota is a large interdisciplinary PhD program, made up of over 125 faculty members. Our goal is to provide students with a broad and deep understanding of Neuroscience, ranging from the molecular and genetic level to computational. Due to its interdisciplinary nature, our program is a highly collaborative and collegial environment in which to train.

Graduate Program in Neuroscience Statement on Diversity and Inclusion             

Like others throughout the world, we the students, faculty, and staff of the Graduate Program in Neuroscience are angered by the unconscionable murder of George Floyd in our city. It is not enough to say Black Lives Matter, but it is important to say it. Inspired by that statement, we are dedicated to increasing our ongoing efforts to improve diversity and inclusion in every aspect of our program.  While these issues are not easily rectified, we are committed to doing all we can to improve our community. 

Despite our best intentions and prior efforts, it is clear that we have significant work ahead of us to promote a just and equitable graduate program. We are taking the first steps by identifying what we can do in our own community. Together with the office of Biomedical Graduate Research, Education, and Training (BGREAT), we are developing and implementing plans to change how we recruit and support students, how we learn and teach, how we recognize accomplishments, and how we reach out to the broader Twin Cities community. We want to make meaningful changes that will last, and lasting change takes time. We are listening, we are learning, and we are committed. 

Specific suggestions are welcome and can be made here https://forms.gle/AtPKh75zzZpbCMfu8

Teaching Research State Fair




We are an interdisciplinary program, with a productive and engaged faculty, committed to providing a supportive environment so that students can achieve their full potential.  Our faculty are from 30 different  departments and have a wide range of research interests and expertise. A complete list of faculty can be found here. We support a number of programs that bring neuroscience into the community, such as Brain Awareness WeekBrains at the State Fair, and the Minnesota State Brain Bee.

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Recent 2020 GPN Publications


  • Kuo SP, Chiang PP, Nippert AR, Newman EA. Spatial organization and dynamics of the extracellular space in the mouse retina. J Neurosci. 2020 Sep 4:JN-RM-1717-20.
  • Wu S, Stone S, Yue Y, Lin W. Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of mature Schwann cells in adults. Glia. 2020 Sep 16. doi: 10.1002/glia.23910.
  • Bala PC, Eisenreich BR, Yoo SBM, Hayden BY, Park HS, Zimmermann J. Automated markerless pose estimation in freely moving macaques with OpenMonkeyStudio. Nat Commun. 2020 Sep 11;11(1):4560.
  • Nietz A, Krook-Magnuson C, Gutierrez H, Klein J, Sauve C, Hoff I, Christenson Wick Z, Krook-Magnuson E. Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype. J Neurophysiol. 2020 Sep 9. doi: 10.1152/jn.00100.2020.
  • Uhelski ML, Bruce D, Speltz R, Wilcox G, Simone DA. Topical application of loperamide/oxymorphindole, mu and delta opioid receptor agonists, reduces sensitization of C-fiber nociceptors that possess NaV1.8. Neuroscience. 2020 Aug 25:S0306-4522(20)30541-8. Neuroimage. 2020 Sep 5:117349.
  • Speltz R, Lunzer MM, Shueb S, Akgun E, Reed R, Kalyuzhny A, Portoghese PS, Simone DA. The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids. Pain. 2020;161:2041-2057.
  • Yacoub E, Grier MD, Auerbach EJ, Lagore RL, Harel N, Adriany G, Zilverstand A, Hayden BY, Heilbronner SR, Ugurbil K, Zimmermann J. Ultra-high field (10.5 T) resting state fMRI in the macaque.
  • Shiroma PR, Thuras P, Wels J, Albott CS, Erbes C, Tye S, Lim KO. Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression. J Affect Disord. 2020;277:470-477.
  • Collins MN, Mesce KA. Focused ultrasound neuromodulation and the confounds of intracellular electrophysiological investigation. eNeuro. 2020 Aug 24;7(4) ENEURO.  0213-20.2020.
  • Zeidler Z, Hoffmann K, Krook-Magnuson E. HippoBellum: acute cerebellar modulation alters hippocampal dynamics and function. J Neurosci. 2020:40(36):6910-6926.
  • Zhang RY, Wei XX, Kay K. Understanding multivariate brain activity: Evaluating the effect of voxelwise noise correlations on population codes in functional magnetic resonance imaging. PLoS Comput Biol. 2020 Aug 18;16(8):e1008153.
  • O'Callaghan B, Hofstra B, Handler HP, Kordasiewicz HB, Cole T, Duvick L, Friedrich J, Rainwater O, Yang P, Benneyworth M, Nichols-Meade T, Heal W, Ter Haar R, Henzler C, Orr HT. Antisense oligonucleotide therapeutic approach for suppression of ataxin-1 expression: A safety assessment. Mol Ther Nucleic Acids. 2020 Jul 25;21:1006-1016.
  • Corlett PR, Mohanty A, MacDonald AW. What we think about when we think about predictive processing. J Abnorm Psychol. 2020 Aug;129(6):529-533.
  • Lines J, Martin ED, Kofuji P, Aguilar J, Araque A. Astrocytes modulate sensory-evoked neuronal network activity. Nat Commun. 2020;11(1):3689.
  • Boroda E, Krueger AM, Bansal P, Schumacher MJ, Roy AV, Boys CJ, Lim KO, Wozniak JR. A randomized controlled trial of transcranial direct-current stimulation and cognitive training in children with fetal alcohol spectrum disorder. Brain Stimul. 2020;13(4):1059-1068.
  • Larson CM, Peterson CD, Kitto KF, Wilcox GL, Fairbanks CA. Sustained-release buprenorphine induces acute opioid tolerance in the mouse. Eur J Pharmacol. 2020 Jul 26:173330.
  • Gross KS, Mermelstein PG. Estrogen receptor signaling through metabotropic glutamate receptors. Vitam Horm. 2020;114:211-232.
  • Hasz BM, Redish AD. Spatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation. Hippocampus. 2020 Aug 18. doi: 10.1002/hipo.23250.
  • Nippert AR, Newman EA. Regulation of blood flow in diabetic retinopathy. Vis Neurosci. 2020 Jul 20;37:E004.
  • Cushnie AK, El-Nahal HG, Bohlen MO, May PJ, Basso MA, Grimaldi P, Wang MZ, de Velasco EMF, Sommer MA, Heilbronner SR. Using rAAV2-retro in rhesus macaques: Promise and caveats for circuit manipulation. J Neurosci Methods. 2020 Jul 12:108859.
  • Corkrum M, Covelo A, Lines J, Bellocchio L, Pisansky M, Loke K, Quintana R, Rothwell PE, Lujan R, Marsicano G, Martin ED, Thomas MJ, Kofuji P, Araque A. Dopamine-evoked synaptic regulation in the nucleus accumbens requires astrocyte activity. Neuron. 2020;105(6):1036-1047.       
  • Bastian TW, Rao R, Tran PV, Georgieff MK. The effects of early-life iron deficiency on brain energy metabolism. Neurosci Insights. 2020 Jun 29;15:2633105520935104.
  • Azab H, Hayden BY. Partial integration of the components of value in anterior cingulate cortex. Behav Neurosci. 2020;134(4):296-308.
  • Roy AV, Thai M, Klimes-Dougan B, Westlund Schreiner M, Mueller BA, Albott CS, Lim KO, Fiecas M, Tye SJ, Cullen KR. Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: Preliminary evidence in adolescents with treatment-resistant depression. J Psychopharmacol. 2020 Jul 9:269881120928203.
  • Tsilibary EC, Souto EP, Kratzke M, James LM, Engdahl BE, Georgopoulos AP. Anthrax protective antigen 63 (PA63): Toxic effects in neural cultures and role in Gulf War illness (GWI). Neurosci Insights. 2020 Jun 30;15:2633105520931966.
  • Monko MM, Heilbronner SR. Some animal models are more equal than others: Cortico-striatal circuits for translation. Lab Anim (NY). 2020 Jul 6. doi: 10.1038/s41684-020-0601-6.
  • Peters ST, Fahrenkopf A, Choquette JM, Vermilyea SC, Lee MK, Vossel K. Ablating Tau reduces hyperexcitability and moderates electroencephalographic slowing in transgenic mice expressing A53T human α-synuclein. Front Neurol. 2020 Jun 19;11:563.
  • Cavaccini A, Durkee C, Kofuji P, Tonini R, Araque A. Astrocyte signaling gates long-term depression at corticostriatal synapses of the direct pathway. J Neurosci. 2020 Jun 15. pii: JN-RM-2369-19.
  • Moeller S, Pisharady Kumar P, Andersson J, Akcakaya M, Harel N, Ma RE, Wu X, Yacoub E, Lenglet C, Ugurbil K. Diffusion Imaging in the Post-HCPEra. J Magn Reson Imaging. 2020 Jun 20. doi: 10.1002/jmri.27247.
  • Öz G, Harding IH, Krahe J, Reetz K. MR imaging and spectroscopy in degenerative ataxias: toward multimodal, multisite, multistage monitoring of neurodegeneration. Curr Opin Neurol. 2020;33(4):451-461.
  • Kummerfeld E, Ma S, Blackman RK, DeNicola AL, Redish AD, Vinogradov S, Crowe DA, Chafee MV. Cognitive control rrrors in nonhuman primates resembling those in schizophrenia reflect opposing effects of NMDA receptor blockade on causal interactions between cells and circuits in prefrontal and parietal cortices. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(7):705-714.
  • Fleuriet J, Willoughby Cl, Kueppers RB, Mustari MJ, McLoon LK. Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates. Sci Rep. 2020 Jul 17;10(1):11927.
  • Rudell JC, Stager D, Felius J, McLoon LK. Morphological differencs in the inferior oblique muscles from subjects with over-elevation in adduction. Invest Ophthalmol Vis Sci. 2020;61(6):33.
  • Collins MN, Mesce KA. Focused ultrasound neuromodulation and the confounds of intracellular electrophysiological investigation. eNeuro. 2020 Jul 31:ENEURO.0213-20.2020.
  • Nahum M, Lee H, Fisher M, Green MF, Hooker CI, Ventura J, Jordan JT, Rose A, Kim SJ, Haut KM, Merzenich MM, Vinogradov S. Online social cognition training in schizophrenia: A double-blind, randomized, controlled multi-site clinical trial. Schizophr Bull. 2020 Jul 2:sbaa085.
  • Puig O, Fisher M, Loewy R, Miley K, Ramsay IS, Carter CS, Ragland JD, Niendam T, Vinogradov S. Early- versus adult-onset schizophrenia as a predictor of response to neuroscience-informed cognitive training. J Clin Psychiatry. 2020 Mar 3;81(2):18m12369.
  • Schallmo MP, Kolodny T, Kale AM, Millin R, Flevaris AV, Edden RAE, Gerdts J, Bernier RA, Murray SO. Weaker neural suppression in autism. Nat Commun. 2020 May 29;11(1):2675.
  • Kolodny T, Schallmo MP, Gerdts J, Edden RAE, Bernier RA, Murray SO. Concentrations of Cortical GABA and glutamate in young adults with autism spectrum disorder. Autism Res. 2020 Apr 16. doi: 10.1002/aur.2300.
  • Kolodny T, Schallmo MP, Gerdts J, Bernier RA, Murray SO. Response dissociation in hierarchical cortical circuits: a unique feature of autism spectrum disorder. J Neurosci. 2020;40(11):2269-2281.
  • Grier MD, Zimmermann J, Heilbronner SR. Estimating brain connectivity with diffusion-weighted magnetic resonance imaging: Promise and peril. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Apr 27. pii: S2451-9022(20)30103-8.
  • Kayed R, Dettmer U, Lesné SE. Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk. J Parkinsons Dis. 2020;10(3):791-818.
  • Anderson A, Masuho I, Marron Fernandez de Velasco E, Nakano A, Birnbaumer L, Martemyanov KA, Wickman K. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells. Proc Natl Acad Sci U S A. 2020 Jun 8. pii: 202001270.

GPN News

Paul Iaizzo, Ph.D., Visible Heart Lab, Medical School

Paul Iaizzo, Ph.D., Visible Heart Lab, Medical School
Researchers look to hibernating bears for advancements in human medicine. is interviewed. KMSP-TV

Congratulations to Martha Streng for being awarded a Milne & Brandenburg Research Award

The Beatrice Z. Milne and Theodore Brandenburg Award recognizes exceptional research by graduate students in the basic biomedical sciences. The award reflects the thoughtfulness and generosity of Ms. Beatrice Z. Milne and serves as a lasting expression of her commitment to improving the health of the people of Minnesota, the nation, and the world.


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