Welcome to the GPN!

 

The Graduate Program in Neuroscience (GPN) at the University of Minnesota is a large interdisciplinary PhD program, made up of over 120 faculty members. Our goal is to provide the students with a broad and deep understanding of Neuroscience, ranging from the molecular and genetic level to computational. Due to its interdisciplinary nature, our program is a highly collaborative and collegial environment in which to train.

Teaching Research State Fair

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Research

Community
We are an inter-disciplinary program, with a productive and engaged faculty, committed to providing a supportive environment so that students can achieve their full potential.  Our faculty are from 30 different  departments and have a wide range of research interests and expertise. A complete list of faculty can be found here. We support a number of programs that bring neuroscience into the community, such as Brain Awareness Week, Brains at the State Fair, and the Minnesota State Brain Bee.

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Recent GPN Publications
  • Kay K, Jamison KW, Vizioli L, Zhang R, Margalit E, Ugurbil K. A critical assessment of data quality and venous effects in sub-millimeter fMRI. Neuroimage. 2019 Feb 4. pii: S1053-8119(19)30092-8.
  • Mellesmoen A, Sheeler C, Ferro A, Rainwater O, Cvetanovic M. Brain derived neurotrophic factor (BDNF) delays onset of pathogenesis in transgenic mouse model of apinocerebellar ataxia type 1 (SCA1). Front Cell Neurosci. 2019 Jan 21;12:509.
  • Popa LS, Ebner TJ. Cerebellum, predictions and errors. Front Cell Neurosci. 2019 Jan 15;12:524.
  • Tzagarakis C, Thompson A, Rogers RD, Pellizzer G. The degree of modulation of beta band activity during motor planning is related to trait impulsivity. Front Integr Neurosci. 2019 Jan 17;13:1.
  • Pflepsen KR, Peterson CD, Kitto KF, Vulchanova L, Wilcox GL, Fairbanks CA. Detailed method for intrathecal delivery of gene therapeutics by direct lumbar puncture in mice. Methods Mol Biol. 2019;1937:305-312.
  • Green MV, Raybuck JD, Zhang X, Wu MM, Thayer SA. Scaling synapses in the presence of HIV. Neurochem Res. 2019;44(1):234-246.
  • Yue Y, Stanojlovic M, Lin Y, Karsenty G, Lin W. Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE. J Neuroinflammation. 2019 Feb 1;16(1):23.
  • Ferro A, Sheeler C, Rosa JG, Cvetanovic M. Role of microglia in ataxias. J Mol Biol. 2019 Jan 17. pii: S0022-2836(19)30025-7.
  • Moghimi P, Lim KO, Netoff TI. Data driven classification using fMRI network measures: Application to schizophrenia. Front Neuroinform. 2018 Oct 30;12:71.
  • Benson NC, Jamison KW, Arcaro MJ, Vu AT, Glasser MF, Coalson TS, Van Essen DC, Yacoub E, Ugurbil K, Winawer J, Kay K. The human connectome project 7 tesla retinotopy dataset: Description and population receptive field analysis. J Vis. 2018 Dec 3;18(13):23. doi: 10.1167/18.13.23.
  • Gross KS, Moore KM, Meisel RL, Mermelstein PG. mGluR5 mediates dihydrotestosterone-induced nucleus accumbens structural plasticity, but not conditioned reward. Front Neurosci. 2018 Nov 20;12:855.
  • Been LE, Gibbons AB, Meisel RL. Towards a neurobiology of female aggression. Neuropharmacology. 2018 Nov 28. pii: S0028-3908(18)30892-X.
  • Zhang X, Green MV, Thayer SA. HIV gp120-induced neuroinflammation potentiates NMDA receptors to overcome basal suppression of inhibitory synapses by p38 MAPK. J Neurochem. 2018 Dec 6. doi: 10.1111/jnc.14640.
  • Durkee CA, Araque A. Diversity and specificity of astrocyte-neuron communication. Neuroscience. 2019 Jan 1;396:73-78
  • Cheong I, Deelchand DK, Eberly LE, Marjańska M, Manousakis G, Guliani G, Walk D, Öz G. Neurochemical correlates of functional decline in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2018 Nov 22. pii: jnnp-2018-318795.
  • Barks A, Hall AM, Tran PV, Georgieff MK. Iron as a model nutrient for understanding the nutritional origins of neuropsychiatric disease. Pediatr Res. 2018 Oct 16. doi: 10.1038/s41390-018-0204-8.
  • Smith GB, Hein B, Whitney DE, Fitzpatrick D, Kaschube M. Distributed network interactions and their emergence in developing neocortex. Nat Neurosci. 2018;21(11):1600-1608.
  • Engeland WC, Massman L, Mishra S, Yoder JM, Leng S, Pignatti E, Piper ME, Carlone DL, Breault DT, Kofuji P. The adrenal clock preventsaberrant light-induced alterations in circadian glucocorticoid rhythms. Endocrinology. 2018;159(12):3950-3964.
  • Teravskis PJ, Covelo A, Miller EC, Singh B, Martell-Martínez HA, Benneyworth MA, Gallardo C, Oxnard BR, Araque A, Lee MK, Liao D. A53T mutant alpha-synuclein induces tau dependent postsynaptic impairment independent of neurodegenerative changes. J Neurosci. 2018;38:9754-9767.
  • Fleuriet J, McLoon LK. Visualizing neuronal adaptation over time after treatment of strabismus. Invest Ophthalmol Vis Sci. 2018;59:5022-5024.
  • Petruk V, He B, Engel S, He S. Stimulus rivalry and binocular rivalry share a common neural substrate. J Vis. 2018;18:18. doi:10.1167/18.9.18.
  • McLoon LK, Redish AD. Demystifying graduate school: Navigating a PhD in neuroscience and beyond. J. Undergrad. Neurosci. Educ. 2018;16:A203-A209.
  • Meitzen J, Meisel RL, Mermelstein PG. Sex differences and the effects of estradiol on striatal function. Curr Opin Behav Sci. 2018;23:42-48.
  • Eisinger KRT, Woolfrey KM, Swanson SP, Schnell SA, Meitzen J, Dell'Acqua M, Mermelstein PG. Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors. J Biol Chem. 2018;293(41):15901-15911.
  • Zeidler Z, Brandt-Fontaine M, Leintz C, Krook-Magnuson C, Netoff T, Krook-Magnuson E.Targeting the mouse ventral hippocampus in the intrahippocampal kainic acid model of temporal lobe epilepsy. eNeuro. 2018 Aug 8;5(4). pii: ENEURO.0158-18.2018.
  • Fitzpatrick KR, Cucak A, McLoon LK. Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle. PLoS One. 2018 Aug 24;13(8):e0202861.
  • Grissom NM, Reyes TM. Let's call the whole thing off: evaluating gender and sex differences in executive function. Neuropsychopharmacology. 2019;44(1):86-96.
  • James LM, Dolan S, Leuthold AC, Engdahl BE, Georgopoulos A, Georgopoulos AP. The effects of human leukocyte antigen DRB1*13 and apolipoprotein E on age-related variability of synchronous neural interactions in healthy women. EBioMedicine. 2018 Aug 20. pii: S2352-3964(18)30313-X.
  • Yue Y, Stone S, Lin W. Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis. Neural Regen Res. 2018 Sep;13(9):1507-1515.
  • Yoo SBM, Hayden BY. Economic choice as an untangling of options into actions. Neuron. 2018;99(3):434-447.
  • Sweis BM, Thomas MJ, Redish AD. Beyond simple test of value: measuring addiction as a heterogeneous disease of computation-specific valuation processes. Learn. Mem. 2018;25:510-512.
  • Nippert AR, Mishra A, Newman EA. Keeping the brain well fed: The role of capillaries and arterioles in orchestrating functional hyperemia. Neuron. 2018;99(2):248-250
  • Sweis BM, Abram SV, Schmidt BJ, Seeland KD, MacDonald, AW III, Thomas MJ, Redish AD. Sensitivity to "sunk costs" in mice, rats, and humans. Science 2018;361:178-181.
  • Kim JH, Lukowicz A, Qu W, Johnson A, Cvetanovic M. Astroglia contribute to the pathogenesis of spinocerebellar ataxia Type 1 (SCA1) in a biphasic, stage-of-disease specific manner. Glia. 2018;66(9):1972-1987.
  • Khan SS, LaCroix M, Boyle G, Sherman MA, Brown JL, Amar F, Aldaco J, Lee MK, Bloom GS, Lesné SE. Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons. Acta Neuropathol. 2018 Jul 11. doi: 10.1007/s00401-018-1886-z.
  • Cash-Padgett T, Azab H, Yoo SBM, Hayden BY. Opposing pupil responses to offered and anticipated reward values. Anim Cogn. 2018;21(5):671-684.
  • Popa LS, Streng ML, Ebner TJ. Purkinje cell representations of behavior: Diary of a busy neuron. Neuroscientist. 2018 Jul 1:1073858418785628.
  • Streng ML, Popa LS, Ebner TJ. Complex spike wars: a new hope. erebellum. 2018;17(6):735-746.
  • Ferro A, Qu W, Lukowicz A, Svedberg D, Johnson A, Cvetanovic M. Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1. PLoS One. 2018 Jul 5;13(7):e0200013.
  • Christenson Wick Z, Krook-Magnuson E. Specificity, versatility, and continual development: The power of optogenetics for epilepsy research. Front Cell Neurosci. 2018 Jun 14;12:151.
  • Covelo A, Araque A. Stimulating astrocytes to remember. Cell. 2018 Jun 28;174(1):12-13.
  • Sweis BM, Redish AD, Thomas MJ. Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict. Nat Commun. 2018 Jun 28;9(1):2521.
  • Sweis BM, Thomas MJ, Redish AD. Mice learn to regret. PLoS Biol. 2018;16(6):e2005853.
  • Ebner SR, Larson EB, Hearing MC, Ingebretson AE, Thomas MJ. Extinction and reinstatement of cocaine-seeking in self-administering mice is associated with Bidirectional AMPAR-mediated plasticity in the nucleus accumbens shell. Neuroscience. 2018 Jun 7;384:340-349.
  • Lipshetz B, Khasabov SG, Truong H, Netoff TI, Simone DA, Giesler GJ Jr. Responses of thalamic neurons to itch- and pain-producing stimuli in rats. J Neurophysiol. 2018;120:1119-1134.
  • Zick JL, Blackman RK, Crowe DA, Amirikian B, DeNicola AL, Netoff TI, Chafee MV. Blocking NMDAR disrupts spike timing and decouples monkey prefrontal circuits: implications for activity-dependent disconnection in Schizophrenia. Neuron. 2018 Jun 27;98(6):1243-1255.
  • Hendrix CM, Campbell BA, Tittle BJ, Johnson LA, Baker KB, Johnson MD, Molnar GF, Vitek JL. Predictive encoding of motor behavior in the supplementary motor area is disrupted in Parkinsonism. J Neurophysiol. 2018 Sep 1;120(3):1247-1255.
  • Yoo SBM, Sleezer BJ, Hayden BY. Robust encoding of spatial information in orbitofrontal cortex and striatum.J Cogn Neurosci. 2018 Jun;30(6):898-913.
  • Pérez Ortiz JM, Mollema N, Toker N, Adamski CJ, O'Callaghan B, Duvick L, Friedrich J, Walters MA, Strasser J, Hawkinson JE, Zoghbi HY, Henzler C, Orr HT, Lagalwar S. Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model. Neurobiol Dis. 2018;116:93-105.
  • Carpenter AF, Baud-Bovy G, Georgopoulos AP, Pellizzer G. Encoding of serial order in working memory: Neuronal activity in motor, premotor and trefrontal cortex during a memory scanning task. J Neurosci. 2018;38(21):4912-4933
  • Vergeer M, Mesik J, Baek Y, Wilmerding K, Engel SA.Orientation-selective contrast adaptation measured with SSVEP.J Vis. 2018 May 1;18(5):2.
  • Wong SZH, Scott EP, Mu W, Guo X, Borgenheimer E, Freeman M, Ming GL, Wu QF, Song H, Nakagawa Y. In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis. PLoS Biol. 2018 Apr 23;16(4):e2005211.
  • Streng ML, Popa LS, Ebner TJ. Modulation of sensory prediction error in Purkinje cells during visual feedback manipulations. Nat Commun. 2018 Mar 15;9(1):1099.
  • Amemiya S, Redish AD. Hippocampal theta-gamma coupling reflects state-dependent information processing in decision making. Cell Rep. 2018;22(12):3328-3338.
  • Rousseaux MWC, Tschumperlin T, Lu HC, Lackey EP, Bondar VV, Wan YW, Tan Q, Adamski CJ, Friedrich J, Twaroski K, Chen W, Tolar J, Henzler C, Sharma A, Bajić A, Lin T, Duvick L, Liu Z, Sillitoe RV, Zoghbi HY, Orr HT. ATXN1-CIC complex Is the primary driver of cerebellar pathology in spinocerebellar ataxia type 1 through a gain-of-function mechanism. Neuron. 2018;97(6):1235-1243.
  • Tonn Eisinger KR, Gross KS, Head BP, Mermelstein PG. Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females. Horm Behav. 2018 Mar 10. pii: S0018-506X(18)30021-7.
  • Gupta A, Mesik J, Engel SA, Smith R, Schatza M, Calabrèse A, van Kuijk FJ, Erdman AG, Legge GE. Beneficial effects of spatial remapping for reading with simulated central field loss. Invest Ophthalmol Vis Sci. 2018;59(2):1105-1112
  • Eisenreich BR, Hayden BY. Cognitive science: Persistent apes are intelligent apes. Curr Biol. 2018;28(4):R160-R162.
  • James LM, Christova P, Lewis SM, Engdahl BE, Georgopoulos A, Georgopoulos AP.Protective effect of human leukocyte antigen (HLA) allele DRB1*13:02 on age-related brain gray matter volume reduction in healthy women. EBioMedicine. 2018 Mar;29:31-37
  • Mesce KA, Alania M, Gaudry Q, Puhl JG. The stomatogastric nervous system of the medicinal leech: its anatomy, physiology and associated aminergic neurons. J Exp Biol. 2018 Mar 29;221(Pt 7). pii: jeb175687.
  • Azab H, Hayden BY. Correlates of economic decisions in the dorsal and subgenual anterior cingulate cortices. Eur J Neurosci. 2018 Apr;47(8):979-993.
  • Pérez Ortiz JM, Orr HT. Spinocerebellar ataxia type 1: Molecular mechanisms of neurodegeneration and preclinical studies. Adv Exp Med Biol. 2018;1049:135-145.
  • Hottman D, Cheng S, Gram A, LeBlanc K, Yuan LL, Li L. Systemic or forebrain neuron-specific deficiency of geranylgeranyltransferase-1 impairs synaptic plasticity and reduces dendritic spine density. Neuroscience. 2018;373:207-217.
  • Hedges VL, Chen G, Yu L, Krentzel AA, Starrett JR, Zhu JN, Suntharalingam P, Remage-Healey L, Wang JJ, Ebner TJ, Mermelstein PG. Local estrogen synthesis regulates parallel fiber-Purkinje cell neurotransmission within the cerebellar cortex. Endocrinology. 2018;159(3):1328-1338.
  • Covelo A, Araque A. Neuronal activity determines distinct gliotransmitter release from a single astrocyte. Elife. 2018 Jan 30;7. pii: e32237

GPN News

Linda McLoon and David Redish have paper published in Journal of Undergraduate Neuroscience Education

Linda McLoon and A. David Redish have paper published in Journal of Undergraduate Neuroscience Education.

McLoon LK, Redish AD. Demystifying graduate school: Navigating a PhD in neuroscience and beyond. J. Undergrad. Neurosci. Educ. 2018;16:A203-A209.

http://www.funjournal.org/wp-content/uploads/2018/06/june-16-203.pdf?x91298

Ben Hayden and Seng Bum Michael Yoo have paper published in Neuron

Ben Hayden and Seng Bum Michael Yoo have a paper published in Neuron.

Seng Bum Michael Yoo, Benjamin Hayden; "Economic choice as an untangling of options into actions", Neuron, August 2018.

Michael Lee and Sylvain Lesné have paper accepted in Acta Neuropathologica

Michael Lee and Sylvain Lesné have paper accepted in Acta Neuropathologica. 

Shahzad S. Khan*, Michael LaCroix*, Gabriel Boyle*, Mathew A. Sherman, Jennifer L. Brown, Fatou Amar, Jacqeline Aldaco, Michael K. Lee, George S. Bloom & Sylvain E. Lesné. "Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons".

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